OsteoBiol

Osteobio

Via MegaGen Benelux B.V. kunt u de OsteoBiol producten van Medical Bone B.V. eenvoudig bestellen. Met als grote voordeel dat u de producten van OsteoBiol tegelijk met uw bestelling van MegaGen kunt plaatsen en dat u van extra voordelen geniet. 

OsteoBiol Aanbiedingen:

Aanbieding – 37% korting op MICAKit en MILAKIT

Aanbieding – 33% korting op MILAKit

Aanbieding – 33% korting op MICAKit

Product overzicht OsteoBiol

Gen-Os

OsteoBiol-Gen-os

Tissue of origin   Cancellous-cortical heterologous bone mix
 
Tissue collagen   Preserved
 
Physical form   Granules slightly radiopaque
 
Composition   100% granulated mix
 
Granulometry   250-1000 micron
 
Re-Entry Time   4/5 months, depending on grafting site characteristics
 
Packaging   vial 0,25 gr. – vial 0,5 gr. – vial 1,0 gr. – vial 2,0 gr.

 

Characteristics

activity. It is biocompatible and bioavailable, as recognized by tests made according to the ISO 10993 method conducted at the Università degli Studi di Torino. <b>Gen-Os</b> is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume (osteoconductive property). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells, favoring restitutio ad integrum of missing bone. Because of its marked &#8220;hydrophilia&#8221;, it can function as a carrier for selected medication and drugs. Image showing bone formation on collagenated porcine bone granules (OsteoBiol® <b>Gen-Os</b>) 2 weeks after implantation in a rabbit. In the lower left and right corners granules can be seen. These granules are covered by newly formed bone and a seam of osteoblasts. Osteocytes in lacunae are visible in the newly formed bone. Close to the osteoblastic seam, both feeding microvessels and a venule can be seen. Staining hematoxyline-eosine. Original magnification x40 (Courtesy of Drs U. Nannmark and L. Sennerby, Göteborg University, Sweden).

 

Characteristics

activity. It is biocompatible and bioavailable, as recognized by tests made according to the ISO 10993 method conducted at the Università degli Studi di Torino. Gen-Os is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume (osteoconductive property). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells, favoring restitutio ad integrum of missing bone. Because of its marked hydrophilia, it can function as a carrier for selected medication and drugs. Image showing bone formation on collagenated porcine bone granules (OsteoBiol® Gen-Os) 2 weeks after implantation in a rabbit. In the lower left and right corners granules can be seen. These granules are covered by newly formed bone and a seam of osteoblasts. Osteocytes in lacunae are visible in the newly formed bone. Close to the osteoblastic seam, both feeding microvessels and a venule can be seen. Staining hematoxyline-eosine. Original magnification x40 (Courtesy of Drs U. Nannmark and L. Sennerby, Göteborg University, Sweden).

 

Handling

Gen-Os must always be hydrated and thoroughly mixed with a few drops of sterile physiological solution to activate its collagen matrix and to enhance its adhesivity; it can also be mixed either with OsteoBiol® Gel 0 or with patient&#8217;s blood. If necessary it can as well be mixed with the drug selected for surgery.

 

Advantages

Gen-Os expands up to 50% in volume after hydration with sterile saline: hydrated collagen contained in each granule also increases sensibily biomaterial adhesivity.

 

Product list

CODE PACKAGING  DESCRIPTION   BONE ORIGIN
M1005FE  1 Vial DRIED GRANULES 0.5 gr Equine
M1005FS 1 Vial  DRIED GRANULES 0.5 gr Porcine
M1010FE 1 Vial   DRIED GRANULES 1.0 gr Equine
M1010FS 1 Vial   DRIED GRANULES 1.0 gr Porcine
M1020FE 1 Vial  DRIED GRANULES 2.0 gr Equine
M1020FS 1 Vial DRIED GRANULES 2.0 gr Porcine
M1052FE 1 Vial   DRIED GRANULES 0.25 gr Equine
M1052FS 1 Vial   DRIED GRANULES 0.25 gr Porcin

mp3

OsteoBiol-mp3

Tissue of origin   Heterologous cortico-cancellous collagenated bone mix
 
Tissue collagen   About 10% (Gel 0)
 
Physical form   Pre-hydrated granules and collagen gel
 
Composition   90% granulated mix, 10% collagen gel
 
Granulometry   600-1000 µm
 
Re-Entry Time   About 5 months
 
Packaging   STERILE SYRINGE 1 cc (EXTERNAL Ø 7 mm – INTERNAL Ø 6 mm)
3 STERILE SYRINGES 0.25 cc (EXTERNAL Ø 7 mm – INTERNAL Ø 6 mm)
3 STERILE SYRINGES 0.5 cc (EXTERNAL Ø 7 mm – INTERNAL Ø 6 mm)
3 STERILE SYRINGES 1.0 cc (EXTERNAL Ø 7 mm – INTERNAL Ø 6 mm)

 

Characteristics
Heterologous origin biomaterial made of 600-1000 µm pre-hydrated collagenated cortico-cancellous granules, properly mixed with OsteoBiol Gel 0. Thus, it is possible both skipping the hydration phase and decreasing the risk of accidental exposure of material to pathogens during manipulation and grafting phases; furthermore the syringe is flexible and ideal to simplify grafting in the receiving site. The granules are endowed with characteristics very similar to human mineral bone, and can be used as an alternative to autologous bone. Their natural micro-porous consistency facilitates new bone tissue formation in defect sites and accelerates the regeneration process. Gradually resorbable, it preserves the original graft shape and volume (osteoconductive property). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells.

 

Handling
mp3 is available in ready-to-use syringes and can be easily grafted avoiding the hydration and manipulation phases. After adapting the material to the defect shape, it is necessary to remove non stable residues before proceeding to soft tissue suture. Courtesy of Dr Roberto Rossi, Private practitioner in Genova (Italy). Histology by Prof. Ulf Nannmark, Goteborg University (Sweden).

 

Productlist

CODE   PACKAGING   DESCRIPTION   BONE ORIGIN  
A3005FE  1 Syringe  BONE MIX 1.0 cc Equine 
A3005FS 1 Syringe  BONE MIX 1.0 cc Porcine 
A3015FE 3 Syringes BONE MIX 3 x 0.5 cc (1.5 cc) Equine 
A3015FS  3 Syringes BONE MIX 3 x 0.5 cc (1.5 cc) Porcine 
A3030FE  3 Syringes   BONE MIX 3 x 1.0 cc (3.0 cc)   Equine 
A3030FS 3 Syringes  BONE MIX 3 x 1.0 cc (3.0 cc) Porcine 
A3075FS 3 Syringes  BONE MIX 3 x 0.25 cc (0,75 cc) Porcine 

Putty

OsteoBiol-putty

Tissue of origin   Mix of cancellous and cortical porcine bone
 
Tissue collagen   Preserved
 
Physical form   Bone putty with plastic consistency composed of collagen gel loaded with 80% micronized porcine bone mix
 
Composition   80% granulated mix, 20% collagen gel
 
Granulometry   ≤ 300 µm
 
Re-Entry Time   About 4 months
 
Packaging  

SYRINGE 0,5 c

c (1 gr.) – VIAL 1,0 cc (2 gr.) – 3 SYRINGES 0,5 cc (3 gr.) – 3 SYRINGES 0,25 cc (1,5 gr.)

 

Characteristics

Putty is a bone paste with at least 80% micronized heterologous bone (granulometry ≤ 300 µm) and collagen gel (Gel 0).
It is made with an exclusive process that provides the product with exceptional malleability and plasticity, making it easy to apply in sockets and peri-implant defects with walls.
Thanks to its collagen component, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells.
Successful grafting needs complete stability of the biomaterial: for this reason Putty must be used only in cavities able to firmly contain it. Therefore, Putty must not be grafted in two wall defects or in lateral access sinus lift procedures.

 

Handling

Inject the product and adapt it to defect morphology without compression; any non stable residue must be removed before soft tissue suture. An Evolution membrane is recommended to protect Putty grafted in peri-implant defects. Part of a biopsy showing newly formed bone after treatment with Putty. Biopsies were taken 5 weeks after implantation in rabbit maxillae. The smaller granules are totally covered by newly formed bone and seams of osteoblasts are recorded almost at all bone surfaces. Both the marrow spaces and bone are fully nurtured by neovessels. Htx-eosine. Original magnification x20.

 

Productlist

CODE PACKAGING DESCRIPTION BONE ORIGIN
HPT09E 1 Syringe BONE PASTE 0.5 cc (1.0 gr) Equine
HPT09S 1 Syringe BONE PASTE 0.5 cc (1.0 gr) Porcine
HPT32E 3 Syringes BONE PASTE 3 x 0.25 cc (1.5 gr) Equine
HPT32S 3 Syringes BONE PASTE 3 x 0.25 cc (1.5 gr) Porcine
HPT35E 3 Syringes BONE PASTE 3 x 0.5 cc (3.0 gr) Equine
HPT35S 3 Syringes BONE PASTE 3 x 0.5 cc (3.0 gr) Porcine
HPT52S 1 Syringe BONE PASTE 0.25 cc (0.5 gr) Porcine

Evolution

OsteoBiol-evolution

Tissue of origin   Heterologous mesenchymal tissue
 
Tissue collagen   Preserved
 
Physical form   Dried membrane with one smooth side and one micro-rough side
 
Composition   100% mesenchymal tissue
 
Thickness   standard (0.5-0.7mm) – fine (0.3-0.5mm)
 
Estimated Resorption Time   About 4 months (standard) – 3 months (fine)
 
Packaging   STD mm20x20 – STD mm30x30
FINE mm20x20 – FINE mm30x30
STD OVAL mm25x35 – FINE OVAL mm25x35

 

Characteristics
Obtained from mesenchymal tissue the Evolution membrane is completely resorbable. Its structure is made of dense collagen fibers of high consistency and of extraordinary resistance that offer the specialist surgeon:
– the maximum adaptability to bone tissue and soft tissues
– an easy and secure suturability to nearby tissues
– the best membrane/bone and membrane/periosteum interface
– stability and prolonged protection of the underlying graft

 

Handling
Membrane can be shaped with sterile scissors until the desired size is reached; it must then be rehydrated with lukewarm physiological solution. Once it O11_03acquires the desired plasticity, it must be adapted to the grafting site. N.B.: in case of accidental exposure, the dense collagenic matrix of Evolution protects the graft from infection; the membrane itself will also not be infected, allowing second intention healing.

 

THICKNESS
The average reported values are indicative and subject to a variability range depending on the composition of the tissues of origin.

 

ESTIMATED RESORPTION TIME
The reported values are estimates and purely indicative: these values can therefore vary depending on the patient and grafting site

 

Productlist

CODE   PACKAGING DESCRIPTION  TISSUE ORIGIN 
EM02HS 1 Blister DRIED / STANDARD 20 x 20 mm   Porcine
EM03HS 1 Blister   DRIED / STANDARD 30 x 30 mm Porcine
EMOHS 1 Blister DRIED / STANDARD Oval 25 x 35 mm Porcine 
EV02HHE 1 Blister   DRIED / STANDARD 20 x 20 mm Equine 
EV02LLE 1 Blister  DRIED / FINE 20 x 20 mm   Equine 
EV03HHE 1 Blister   DRIED / STANDARD 30 x 30 mm Equine 
EV03LLE 1 Blister  DRIED / FINE 30 x 30 mm   Equine 
EVOLLE 1 Blister DRIED / FINE Oval 25 x 35 mm Equine

Cortical Lamina

OsteoBiol-lamina

Tissue of origin

  Cortical bone
 
Tissue collagen   Preserved
 
Physical form   Rigid dried lamina (curved) – Flexible after re-hydration (STD and FINE)
 
Thickness  

STANDARD SOFT (2-4 mm)

MEDIUM CURVED (0.8-1.0 mm)

FINE SOFT (0.4-0.6mm)

 
Estimated Resorption Time   STD about 8 months – MEDIUM and FINE about 6 months
 
Packaging   STANDARD mm 30×30
MEDIUM CURVED mm 30×30
FINE mm 25×25 – mm 20×40 – oval 35×25

 

Characteristics
Soft Cortical Laminae (Standard and Fine models) are made of cortical bone of heterologous origin produced with an exclusive Tecnoss process that avoids the ceramization of hydroxyapatite crystals, thus accelerating physiological resorption. After a process of superficial decalcification, it acquires an elastic consistency, nevertheless maintaining the typical consistency of the bone tissue from which it originates; the margins are soft in order not to cause micro traumas to the surrounding tissues. Curved Lamina has a semi-rigid consistency and can be grafted without hydration, provided that its shape fits the defect morphology.

 

Handling
Soft Cortical Lamina can be shaped with sterile scissors until the desired size is reached, then it must be hydrated for 5/10 minutes in sterile physiological solution. Once it acquires the desired plasticity, it must be adapted to the grafting site; it should always be immobilized either with titanium microscrews or sutured (Fine model) directly to the surrounding tissues with a triangular section non-traumatic needle. Curved Lamina should not be hydrated but can also be shaped with sterile scissors, and must be fixated with osteosynthesis screws. In case of exposure, Lamina should only be removed if there is a clear suprainfection, because its consistency is such as to allow it to achieve a complete second intention healing of the wound.

 

Productlist

CODE PACKAGING DESCRIPTION BONE ORIGIN
LS10HE 1 Blister DRIED / MEDIUM 35 x 35 x (0.8-1.0) mm Equine
LS10HS 1 Blister DRIED / MEDIUM 35 x 35 x (0.8-1.0) mm Porcine
LS23FE 1 Blister DRIED / FINE Oval 25 x 35 x (0.4-0.6) mm Equine
LS23FS 1 Blister DRIED / FINE Oval 25 x 35 x (0.4-0.6) mm Porcine
LS24FE 1 Blister DRIED / FINE 20 x 40 x (0.4-0.6) mm Equine
LS24FS 1 Blister DRIED / FINE 20 x 40 x (0.4-0.6) mm Porcine
LS25FE 1 Blister DRIED / FINE 25 x 25 x (0.4-0.6) mm Equine
LS25FS 1 Blister DRIED / FINE 25 x 25 x (0.4-0.6) mm Porcine

Sp-Block

OsteoBiol-sp-block

Tissue of origin   Heterologous cancellous block
 
Tissue collagen   Preserved
 
Physical form   Rigid dried block
 
Composition   100% cancellous bone
 
Re-Entry Time   Variable depending on characteristics and irroration grade of grafting site and on clinical conditions of patient – about 8 months
 
Packaging   COLLAGENATED BLOCKS mm 10x10x10mm – 10x10x20 – mm 20x20x10 – mm 35x10x5

 

Characteristics
Collagenated block: cancellous block of equine bone produced with an exclusive Tecnoss process which avoids ceramization of the hydroxyapatite crystals, thus accelerating physiological resorption.
Sp-Block supports new bone formation: thanks to its rigid consistency it is able to maintain in time the original graft volume, which is particularly important in case of large regenerations. Moreover, its collagen content facilitates blood clotting and the subsequent invasion of regenerative and repairing cells, favoring restitutio ad integrum of missing bone. The blocks complete biocompatibility and bioavailability have been demonstrated by tests conducted at the Università degli Studi di Torino, according to the ISO 10993 method. Because of their marked “hygroscopicity”, they can function as carriers of selected medication and drugs.

 

Handling
Sp-Block must be hydrated before use for 5/10 minutes with sterile lukewarm physiological solution or with antibiotics. Afterwards, it can be adapted to the receiving site which must be accurately decorticated in order to guarantee maximum contact; the block must always be fixed with osteosynthesis microscrews and should be protected with a resorbable barrier (Evolution membrane).

 

Productlist

CODE PACKAGING DESCRIPTION BONE ORIGIN
BN0E 1Blister DRIED BLOCK / NORM 10 x 10 x 10 mm Equine
BN1E 1Blister DRIED BLOCK / NORM 10 x 10 x 20 mm Equine
BN2E 1Blister DRIED BLOCK / NORM 10 x 20 x 20 mm Equine
BN8E 1Blister DRIED BLOCK / NORM 35 x 10 x 5 mm Equine

Dual-Block

OsteoBiol-dual-block

Tissue of origin   Heterologous cortico-cancellous block
 
Tissue collagen   Preserved
 
Physical form   Rigid dried block
 
Composition   100% cortico-cancellous bone
 
Re-Entry Time   Variable depending on characteristics and irroration grade of grafting site and on clinical              conditions of patient – about 8 months
 
Packaging   COLLAGENATED BLOCKS  20x15x5mm curved –  20x10x5mm curved

 

Characteristics
cortico-cancellous block of equine or porcine bone produced with an exclusive Tecnoss process which avoids ceramization of theO18_02 hydroxyapatite crystals, thus accelerating physiological resorption. Dual-Block supports new bone formation: thanks to its rigid consistency it is able to maintain in time the original graft volume, which is particularly important in case of large regenerations. Moreover, its collagen content facilitates blood clotting and the subsequent invasion of regenerative and repairing cells, favoring restitutio ad integrum of missing bone. The blocks complete biocompatibility and bioavailability have been demonstrated by tests conducted at the Università degli Studi di Torino, according to the ISO 10993 method. Because of their marked “hygroscopicity”, they can function as carriers of selected medication and drugs.

 

Productlist

CODE   PACKAGING DESCRIPTION BONE ORIGIN  
STN5S 1 Blister CURVED DRIED BLOCK / NORM 20 x 10 x 5 mm   Porcine
STS7S 1 Blister   CURVED DRIED BLOCK / SOFT 20 x 15 x 5 mm   Porcine

Derma

OsteoBiol-derma

Tissue of origin   Porcine derma
 
Tissue collagen   Preserved
 
Physical form   Dried membrane
 
Composition   100% derma
 
Thickness   Standard (2mm) – Fine (0,8-1mm)
 
Estimated Resorption Time   Standard about 5 months – Fine about 3 months
 
Packaging   STD mm30x30
FINE mm25x25

 

Characteristics
Obtained from derma of porcine origin, using an exclusive Tecnoss process, Derma membranes are completely resorbable. Their strong consistency and resistance allow a perfect stabilization and a prolonged protection of underlying graft in large regeneration procedures, together with a strong barrier action to guide the growth of epithelium and preventing its invagination.

 

Handling
Derma membrane can be shaped with scissors until the desired size is reached; then it must be hydrated for 15 minutes in sterile lukewarm physiological solution. Once it acquires the desired plasticity, it must be adapted to the grafting site. It is always recommendable to prepare a pocket with an elevator in order to stabilize the membrane in the site after stitching the flaps. If this is not possible, the membrane can be stitched with envelope sutures which bridle it with the gingival flaps. N.B.: if Derma membrane, for any reason, shows dehiscences (for example in the secondary tearing of flaps) it must absolutely not be removed, because its plasticity and consistency is such as to allow it to achieve a complete second intention healing of the wound, because of the physiological sliding of the flaps.

 

Clinical applications
Oral Surgery and Traumatology: stabilization and protection of large regenerations with risk of exposure. Implantology: protection of two wall defects graft. Periodontology: space making in gingival recessions (x-fine model).

 

Productlist

CODE PACKAGING DESCRIPTION TISSUE ORIGIN
ED03SS 1 Blister DRIED / STANDARD 30 x 30 x (2.0) mm Porcine
ED15SS 1 Blister DRIED / STANDARD 15 x 5 x (2.0) mm Porcine
ED25FS 1 Blister DRIED / FINE 25 x 25 x (0.8-1.0) mm Porcine
ED75SS 1 Blister DRIED / STANDARD 7 x 5 x (2.0) mm Porcine
 

Apatos

apatos

Tissue of origin   Porcine cortical and cancellous bone
 
Tissue collagen   Degraded
 
Physical form   Radiopaque granules of mineral hydroxyapatite
 
Granulometry   600-1000 µm
 
Re-Entry Time   About 4 months Apatos Spongiosa 
5 months Apatos Mix 
6 months Apatos Cortical
 
Packaging   Cancellous: vial 0,5 gr. – vial 1,0 gr.
Mix: vial 0,5 gr. – vial 1,0 gr. – vial 2,0 gr.
Cortical: vial 0,5 gr. – vial 1,0 gr.

 

Characteristics
Apatos is a biomaterial of heterologous origin with characteristics similar to mineralized human bone; it can therefore be used as alternative to autologous bone.
The natural microporous consistency of Apatos facilitates the formation of new bone tissue in bone defect area, accelerating the process.
Apatos nanocrystalline hydroxyapatite is available in cancellous, cortical and mixed granules.

 

Handling
Apatos must always be hydrated and thoroughly mixed with a few drops of sterile saline; it can also be mixed with patient’s blood. Finally it can be mixed if necessary with the drug selected for surgery; the mixture thus obtained should be positioned with a sterile spatula or syringe for biomaterials.

 

Clinical applications
Oral surgery: granulomas, dentigerous cysts and split crests. Implantology: universal filler used in treatment of dehiscences and periimplantitis, two wall defects, lateral and crestal access sinus lift. In particular Apatos is characterized by a very long resorption time, guaranteeing optimal preservation of the graft volume. When needed, Apatos graft can be protected with OsteoBiol® Evolution membrane or Soft Cortical Lamina.

 

 

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