Gen-Os

Characteristics

activity. It is biocompatible and bioavailable, as recognized by tests made according to the ISO 10993 method conducted at the Università degli Studi di Torino. Gen-Os is gradually resorbable and provides support in bone neoformation helping to preserve the original graft shape and volume (osteoconductive property). Moreover, thanks to its collagen content, the product facilitates blood clotting and the subsequent invasion of repairing and regenerative cells, favoring restitutio ad integrum of missing bone. Because of its marked hydrophilia, it can function as a carrier for selected medication and drugs. Image showing bone formation on collagenated porcine bone granules (OsteoBiol® Gen-Os) 2 weeks after implantation in a rabbit. In the lower left and right corners granules can be seen. These granules are covered by newly formed bone and a seam of osteoblasts. Osteocytes in lacunae are visible in the newly formed bone. Close to the osteoblastic seam, both feeding microvessels and a venule can be seen. Staining hematoxyline-eosine. Original magnification x40 (Courtesy of Drs U. Nannmark and L. Sennerby, Göteborg University, Sweden).

Handling

Gen-Os must always be hydrated and thoroughly mixed with a few drops of sterile physiological solution to activate its collagen matrix and to enhance its adhesivity; it can also be mixed either with OsteoBiol® Gel 0 or with patient’s blood. If necessary it can as well be mixed with the drug selected for surgery.

Advantages

Gen-Os expands up to 50% in volume after hydration with sterile saline: hydrated collagen contained in each granule also increases sensibily biomaterial adhesivity.

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